Gut-brain communication in demyelinating disorders

Demyelinating Disorders

as in men and more frequently afflicts Caucasian patients, but all races can be affected. Onset of disease usually occurs in people between 20 and 50 years of age, with a peak occurring in those 30 years of age. The prevalence of MS varies widely with location; the highest prevalence is found at higher latitudes. This geographic variation suggests that MS may in part be caused by the action of ...

Gut Microbiota and Neuropsychiatric Disorders

Dynamics of Gut-Brain Communication Underlying Hunger.

Communication between the gut and brain is critical for homeostasis, but how this communication is represented in the dynamics of feeding circuits is unknown. Here we describe nutritional regulation of key neurons that control hunger in vivo. We show that intragastric nutrient infusion rapidly and durably inhibits hunger-promoting AgRP neurons in awake, behaving mice. This inhibition is proport...

Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction.

Zinc in Gut-Brain Interaction in Autism and Neurological Disorders

A growing amount of research indicates that abnormalities in the gastrointestinal (GI) system during development might be a common factor in multiple neurological disorders and might be responsible for some of the shared comorbidities seen among these diseases. For example, many patients with Autism Spectrum Disorder (ASD) have symptoms associated with GI disorders. Maternal zinc status may be ...